La maladie se manifeste surtout après la quarantaine et toucherait 6 fois plus souvent un homme qu’une femme. This strategy allowed investigators to effectively sample the grandparental DNA from rural Great Britain in the latter part of the nineteenth century, before the start of the major population movements of the twentieth century. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). The Papal Benediction sign, with bent ring and small fingers, may have started with a pope with the condition 10050238. Whaley and Elliot (1993) provided an account of four ‘miracles’ from Nordic sources, where a condition resembling DD was alleviated by miracle cures. First, we compared the summed total FST for Norse ancestry informative markers from PoBI in cases and controls in BSSH-GODD. What other conditions predispose to Dupuytren? If DD were of Norse origin, we would expect that cases would have a higher average total FST than controls. First, epidemiological studies have shown that DD is more common in European populations and the prevalence seems to be highest in Iceland and Scandinavian countries that were the origin of the Viking Warriors (Hindocha et al., 2009). En 1831, le baron Guillaume Dupuytren fut le premier à décrire en détail cette affection caractérisée par des contractures digitales, et le premier aussi à les traiter chirurgicalement. The second stream of evidence is historical. However, there are nine or ten different genes associated with Dupuytren’s and this suggests that it may have evolved on several different occasions. Plater described a stone mason with “contraction of the fingers of the left hand into the palm” [1]. Dupuytren’s disease, Morbus Dupuytren or palmar fibromatosis, sometimes also called DD, Dupuytren’s contracture, or Viking disease, is a chronic disease that produces a benign thickening of the connective tissue, or fascia, of the palm and fingers. To date, genome-wide association studies (GWAS) have revealed 26 loci predisposing to DD (Dolmans et al., 2011; Ng et al., 2017). We found no evidence for an excess of Norse ancestry informative markers in our cases and the total FST of disease-associated SNPs was not in the top 5% of 10,000 randomly permuted SNP groups of the same size. Figure 1. ,{i:'fig2-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig2.gif',l:'10.1177_1753193419882851-fig2.jpeg',size:'1 MB'}]} This work was supported by the NIHR Biomedical Research Centre, Oxford. Furthermore, Elliot (1988) also comments on the lack of records of DD in the medical writings of the missionaries of Iona, the Roman Church in North Germany and North-East England, or the extensive medical writings from mediaeval Europe. We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. For all comparator groups, the 95% confidence intervals of the difference between means crossed zero meaning there was no significant difference. People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population, The British Society for Surgery of the Hand. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} Les fibres longitudinales prennent leur origine au nive au du tendon long palmaire ou, si ce tendon est absent, au niveau des fibres de l aponévrose antébrac hiale. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d'abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. En effet les patients atteints de la maladie de Dupuytren notamment serait plus enclin à développer une maladie de Lapeyronie (l’association Dupuytren – maladie de lapeyronie a été retrouvée dans 10 à 15% des cas). La maladie de Dupuytren est une maladie qui touche généralement les personnes âgées, mais elle peut apparaître dès l’âge de 40 ans environ. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. Maladie de Dupuytren, une orthèse pour maintenir le doigt en extension Une orthèse pour maintenir un doigt en extension après une opération de Dupuytren ©J.Redoux. La contracture de Dupuytren est un état graduel qui influence les doigts et les mains, entraînant au moins un doigt, et probablement plusieurs, à courber vers la paume de la main. I have read and accept the terms and conditions, View permissions information for this article. La Société canadienne de Dupuytren est présentement à la recherche d’un membre pour se joindre à notre comité de levée de fonds La société canadienne Dupuytren a été constituée et a reçu le statut d'organisme de bienfaisance en 2015. Maladie de Dupuytren : définition C'est une fibrose rétractile irréductible de l'aponévrose palmaire de la main avec rétraction et flexion des doigts, perception de nodules durs et épaississement de l'aponévrose palmaire moyenne. ... L’origine de cette maladie est encore inconnue, elle peut être d’origine génétique et pouvant atteindre plusieurs membres d’une famille. Please read and accept the terms and conditions and check the box to generate a sharing link. La maladie de Dupuytren (également connue sous le nom de contracture de Dupuytren) est un état bénin de la peau caractérisée par la surcroissance des myofibroblasts It’s also a complete fantasy. Le travail prolongé avec les mains n’est pas responsable de la maladie de Dupuytren. Lactase is under positive selection and therefore is expected to show much less population-specific haplotype sharing, and is therefore a positive control in this analysis. The authors wish to acknowledge all of the individuals who participated in both studies. (Fig. I’ve counted 113 medical journal articles published since 1985 which associate Dupuytren with the Vikings. Townley, WA, Baker, R, Sheppard, N, Grobbelaar, AO. Also, Hindocha et al., (2009) stated: ‘Other than the common prevalence of DD in Scandinavia, no objective scientific evidence has been found to date to support and substantiate the “Nordic” origin of the disease’. Access to society journal content varies across our titles. L’analyse statistique a été faite sur logiciel Epi info et SPSS. Les invasions des Vikings restent le facteur … The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." Garagnani, P, Laayouni, H, Gonzalez-Neira, A. Gebereegziabher, A, Baraki, A, Kebede, Y, Mohammed, I, Finsen, V. Lawson, DJ, Hellenthal, G, Myers, S, Falush, D. Timpson, NJ, Greenwood, CMT, Soranzo, N, Lawson, DJ, Richards, JB. Tombe viking de Locmaria (ile de Groix), ... La première, maladie de Dupuytren (du nom du chirurgien, Le baron Guillaume Dupuytren(1777-1835) qui l’a décrite en 1831) ... entrainant des réactions du corps à l’origine de ces maladies. RU; DE; FR; ES; Remember this site Search! Contact us if you experience any difficulty logging in. In Orkney vs Wales, the DD-associated set was on the 74th centile; in Orkney vs South East, it was on the 81st centile; and in Orkney vs Wales and South East, it was on the 92nd centile. (J Hand Surg 2002;27A:385–390. Cette maladie est en partie d’origine génétique et apparaît le plus souvent vers la cinquantaine chez l’homme et plus tardivement chez la femme. By continuing to browse La maladie de Dupuytren est caractérisée par une rétraction des doigts secondaire à une prolifération de tissu fibreux rétractile dans l’aponévrose palmaire et ses prolongements dans les doigts. La Dystonie . We hypothesized that if DD were of Norse origin, cases would have a higher average total FST than controls. La maladie de Dupuytren est une maladie d`origine inconnue qui. NORTHERN or Scottish people are more likely to develop ‘viking’ - or Dupuytren's - disease, which affects one million in the UK. (a) Dupuytren’s genetic risk score is not significantly different from random in a haplotype-based test for population structure. Dupuytren's contracture (also called Dupuytren's disease, Morbus Dupuytren, Viking disease, and Celtic hand) is a condition in which one or more fingers become permanently bent in a flexed position. Lore has it that they spread it throughout northern Europe. Elles s ét endent sur toute la largeur de la paume, en éventail. Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711. James Barrie, author of “Peter Pan” had a right contracture thought to be Dupuytren’s, which formed the source material for Captain Hook’s hook. It has been suggested that Dupuytren’s disease has an origin in Norse countries. Compared with 500 random samples of 21 SNPs taken from across the genome, the DD-associated SNPs do not show an increase in within-population structure (p = 0.072, Figure 2(a)), which would have been expected had DD been associated with Norse ancestry. On l'appelle aussi parfois "la maladie des Vikings" car elle touche majoritairement les hommes d'Europe du Nord, de plus de 40 ans. Elles s … The local painting for the 21 independent Dupuytren’s GWAS hits was extracted and the frequency for which individuals with each population label shared a most recent haplotype with individuals of each other population was calculated, to form a population co-ancestry matrix for each position in the genome. Table 2. For each comparator group, the total FST of the DD-associated SNPs was not within the top 5% of ranked total FST of 10,000 permuted SNP groups (nominally p > 0.05, Figure 1(b,c,d). Furthermore, chromosome painting did not find evidence for localized genetic population structure that would be expected around DD-associated SNPs if there were an excess of Norse ancestry. D’autres pathologies d’altération de gènes responsables de dégradation du collagène ont été également retrouvées. In conclusion, our genetic analyses directly contradict the widely held belief, especially popular among patients, that DD is a disease of Norse origin. Some scepticism as to the Norse origin of the disease has been expressed by Elliot (1988). Résultats L’échantillon concerne 3025 agents. forum pour la maladie de Dupuytren et maladie de Ledderhose; Dupuytren Society ... Dupuytren Society se réserve le droit de supprimer tout message contenant de la publicité, ainsi que toute information dont le contenu serait illicite ou inadéquat. (b) Orkney vs Wales; (c) Orkney vs South East; (d) Orkney vs Wales and South East. Next, to assess for localized population structure at the DD-associated loci in the PoBI dataset, we used chromosome painting, comparing the frequency of haplotypes most recently shared within population groups to that between population groups (Lawson et al., 2012). Elles Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. The medical terminology used for this kind of a hand deformity is Dupuytren's contracture. Within the UK there are geographical population clusters that can be separated on the basis of their inherited genetic variation (Leslie et al., 2015). Dupuytren's disease typically starts at the age of 50 to 60, though even children have been reported to suffer from Dupuytren's disease (example of a 10 year old boy: "Dupuytren's disease in a child: a case report" Dupuytren_child_abstract). L’atteinte d’autres membres de la famille, avec des formes de sévérité variable, semble indiquer une origine génétique. For each analysis, FST was calculated between three comparator groups: Orkney vs Wales, Orkney vs South East, and Orkney vs combined Wales and South East. The aggregated GRS across the PoBI dataset does not show any geographical clustering in areas of known high Norse ancestry (Figure 2(c)), which would have been expected if the genetic predisposition to DD was derived from Norse ancestry. Elle entraîne une rétraction et une flexion progressive et irréductible des doigts. La maladie de Dupuytren est une sorte de pathologie qui se caractérise par la rétraction progressive d’un ou plusieurs ou doigts de la main. (J Hand Surg 2002;27A:385–390. The haplotype structure of PoBI participants at relevant loci was examined. The email address and/or password entered does not match our records, please check and try again. This product could help you, Accessing resources off campus can be a challenge. La maladie de Dupuytren et le syndrome du canal carpien peuvent survenir chez le même patient. Toutefois, aucun lien de cause à effet n'a été démontré entre ces deux maladies. He commented on the fact that ‘It is surprising that no earlier reference to this condition has been found in the Scandinavian literature’. The evidence for this assertion comes from two main themes. Le travail manuel n’est pas responsable de la maladie de Dupuytren. In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren’s disease. James Barrie, author of “Peter Pan” had a right contracture thought to be Dupuytren’s, which formed the source material for Captain Hook’s hook. Some society journals require you to create a personal profile, then activate your society account, You are adding the following journals to your email alerts, Did you struggle to get access to this article? This is contrast to the lactase-associated SNP rs4988235, which as expected shows a highly significant decrease in population-specific haplotype sharing (p < 0.001, Figure 2(b)). We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. La maladie de Dupuytren. Cet épaississement s’accompagne d’une rétraction qui limite l’extension des doigts et peut infiltrer la peau. http://www.creativecommons.org/licenses/by/4.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, https://www.hsph.harvard.edu/alkes-price/software/, Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren’s disease, Radiotherapy in Dupuytren’s disease: a systematic review of the evidence, Egawa T, Senuri S, Horiki A, Egawa M. Epidemiology of the Oriental patient. In addition, we thank the surgeons and researchers in the BSSH-GODD study who helped with recruitment of affected individuals. ,{i:'fig1-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig1.gif',l:'10.1177_1753193419882851-fig1.jpeg',size:'207 KB'}]} La maladie de Dupuytren est une fibrose se présentant au niveau de l’aponévrose moyenne de la paume de la main. La maladie de Dupuytren est une maladie d'origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Causes et facteurs de risque de la maladie de Dupuytren. Selon ce spécialiste de l’appareillage de la main et du membre supérieur, “le doigt à la. Data used in this study are available from the European Genome-Phenome Archive (https://ega-archive.org), study numbers EGAS00001000672 and EGAS00001001206, The distribution of genomic FST in both cases and controls closely followed a normal distribution (Figure 1(a)). The e-mail addresses that you supply to use this service will not be used for any other purpose without your consent. Maladie de Dupuytren : causes, symptômes, traitement Maladie de Dupuytren : causes, symptômes, traitementnoté 4.5 - 2 votesL’existence de la maladie de Dupuytren n’est pas très connue. (Classification). Exceptionnelle chez les Asiatiques (1 seul cas), les Africains (à peine 8 cas répertoriés) et les Indiens (10 cas décrits) , la maladie de Dupuytren survient seulement chez les sujets blancs, européens du nord (Islande, Scandinavie, Russie, Angleterre) et chez leurs descendants, en particulier dans les pays d'émigration britannique (Canada, États-Unis, Australie). The PoBI dataset consisted of a geographically diverse sample of 2039 individuals from the United Kingdom, which were then compared with 6209 individuals from across Europe to generate signals of historical demographic shifts. Furthermore, the lack of description of a disease resembling DD in Ancient Greek, Roman, Early Anglo-Saxon or Medieval European writings is further putative evidence of a Nordic origin of the disease (Elliot, 1988). De quoi parle t-on ? The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." (b) Lactase-associated SNP rs4988235 shows a highly significant decrease in local haplotype sharing. La pathogenèse de la maladie de Dupuytren repose sur leur s tructure tridimensionnelle. La maladie de Dupuytren atteint 216 d’entre eux, soit une prévalence de 7,1%. He also makes reference to both the ‘fragmentary nature of the record which has survived’ and the fact that life expectancy in previous centuries was much lower than the median age of onset of DD; these are both pertinent points that reveal the weakness of the historical case. The People of the British Isles (PoBI) Study sampled DNA from 2039 individuals throughout rural areas of the UK whose four grandparents were born within 80 km of each other (Winney et al., 2012). It has been suggested that Dupuytren’s disease has an origin in Norse countries. Our results do not provide support for the hypothesis that DD is a ‘disease of the Vikings’. La maladie de Dupuytren a été décrite par le Baron Dupuytren en 1832. To make a fair null hypothesis, we sampled the same number of random genome-wide SNPs that make up the risk score using 500 random samples of 21 SNPs. ]}. The mean difference in total FST between cases and controls ranged between −0.06 and 0.05 (Table 2). We then aggregated these scores across the 35 population labels to investigate possible geographical structure associated with known regions of high Norse ancestry, such as the Highlands of Scotland. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. L'héritage viking (3) : Les Vikings n’ont pas laissé que des vestiges archéologiques. Madrid; Santander; Spécialités . Au fur et à mesure que la maladie évolue, ces tissus se rétractent entraînant la … FST for each SNP was calculated using Hudson’s estimator of FST (Hudson et al., 1992), as implemented in EIGENSOFT (https://www.hsph.harvard.edu/alkes-price/software/). Dupuytren’s Contracture is known by other names including Viking’s Disease and Baron Dupuytren’s Disease. Finally, a GRS derived from DD-associated SNPs did not show increased geographical clustering around areas of known high Norse ancestry. Il s’agit d’une fibrose rétractile de l’aponévrose palmaire moyenne de la main qui est une membrane située entre les tendons fléchisseurs de la main et la peau. You can be signed in via any or all of the methods shown below at the same time. Because we were interested in those SNPs that differentiated Orkney from the other populations, all negative FST values were set to zero (Garagnani et al., 2009). enacademic.com EN. We hypothesized that if DD was caused in individuals by having Norse ancestry at these loci, then we would expect that they have an excess amount of local structure, relative to the genome as a whole.